can php detect whether an email address is a valid one?

From: Date: Wed, 14 Nov 2001 02:31:10 +0000
Subject: can php detect whether an email address is a valid one?
Groups: php.general 
Request: Send a blank email to php-general+get-74528@lists.php.net to get a copy of this message
I have a php script sending newsletter to a mailing list time by time, but some emails are no longer exist, so I need to remove them manually. Can php detect whether an email address is a valid one, then remove it from the list automatically? no matter before or after the newsletter has sent. Thanks in advance.

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