how do you route?

Is there a way to route every web page request through a specific script using PHP / Apache? I'm familiar with using ForceType to route all requests through /news/ to a script called news. Ie.

        <Location /news>
          ForceType application/x-httpd-php
        </Location>

and creating a script called news with no file extension. Is it possible to do this at the domain level rather than requiring that a sub-folder be involved? As example, I'd go to http://www.example.com and my request would get processed by a script. I'd go to http://www.example.com/pizza/ and the request would get processed by the same script. Thanks, -Ed