Optimum configuration for Apache and PHP

Hello all, We are building a new LAMP system, which will contain lots of virtualhosts (most of them are Typo3 vhosts). Hardware: Processors: 2 x Xeon(TM) CPU 3.20GHz, 2048 KB (EM64T, HyperThreading) RAM: 4GB Im wondering what would be the best solution to setup apache and PHP (we want install php4 and php5 on the same machine) I thought about the following possibilities (Configuration_1) - apache2 compiled with "worker mpm" and "threads" - php compiled as "cgi" and "threads" ? what about fastcgi in this configuartion ? ? what about eaccelerator or pecl-apc in this configuartion ? (/Configuration_1) (Configuration_2) - apache2 compiled with "prefork mpm" - php compiled as "cgi" (all without threads) ? what about fastcgi in this configuartion ? ? what about eaccelerator or pecl-apc in this configuartion ? (/Configuration_2) (Configuration_3) - apache2 compiled with "prefork mpm" - php compiled as "mod_php" ? what about eaccelerator or pecl-apc in this configuartion ? (/Configuration_3) Which one is the way to go regarding stability, performance and security? How does mod_suphp affect performance and stability? Thanks for helping us.