Passing arguments to the compiler

I need to pass an argument to the compiler that will contain the location of some standard libraries that my project uses. These libraries are found in /usr/include directories. Information that I have found indicates that I need to pass the -l/usr/include/kde argument. So I was wondering how I can do this, if there is a location in the config.m4 or if I need to modify something else after the ./configure process? Thanks, -Eric